Impact of COVID-19 on global hepatitis C elimination efforts.
Identifieur interne : 000D54 ( Main/Exploration ); précédent : 000D53; suivant : 000D55Impact of COVID-19 on global hepatitis C elimination efforts.
Auteurs : Sarah Blach [États-Unis] ; Loreta A. Kondili ; Alessio Aghemo [Italie] ; Zongzhen Cai [États-Unis] ; Ellen Dugan [États-Unis] ; Chris Estes [États-Unis] ; Ivane Gamkrelidze [États-Unis] ; Siya Ma [États-Unis] ; Jean Michel Pawlotsky [France] ; Devin Razavi-Shearer [États-Unis] ; Homie Razavi [États-Unis] ; Imam Waked [Égypte] ; Stefan Zeuzem [Allemagne] ; Antonio Craxi [Italie]Source :
- Journal of hepatology [ 1600-0641 ] ; 2020.
Abstract
BACKGROUND & AIMS
COVID-19 has placed significant strain on national healthcare systems at a critical moment in the context of hepatitis elimination. Mathematical models can be used to evaluate the possible impact of programmatic delays on hepatitis disease burden. The objective of this analysis was to evaluate the incremental change in hepatitis C liver-related deaths and liver cancer, following a 3-month, 6-month, or 1-year hiatus in hepatitis elimination program progress.
METHODS
Previously developed models were adapted for 110 countries to include a status quo or "no delay" scenario and a "1-year delay" scenario assuming significant disruption in interventions (screening, diagnosis and treatment) in the year 2020. Annual, country-level, model outcomes were extracted, and weighted averages were used to calculate regional (WHO and World Bank Income Group) and global estimates from 2020 to 2030. The incremental annual change in outcomes was calculated by subtracting the "no-delay" estimates from the "1-year delay" estimates.
RESULTS
The "1-year delay" scenario resulted in 44,800 (95% UI: 43,800 - 49,300) excess hepatocellular carcinoma (HCC) cases and 72,300 (95% UI: 70,600 - 79,400) excess liver-related deaths (LRDs), relative to the "no delay" scenario globally, from 2020-2030. Most missed treatments would be in lower-middle income countries, while most excess HCC and LRDs would be among high-income countries.
CONCLUSIONS
The impact of COVID-19 extends beyond the direct morbidity and mortality associated with exposure and infection. In order to mitigate the impact on viral hepatitis programming and reduce excess mortality from delayed treatment, policy makers should prioritize hepatitis programs as soon as it becomes safe to do so.
DOI: 10.1016/j.jhep.2020.07.042
PubMed: 32777322
PubMed Central: PMC7411379
Affiliations:
- Allemagne, France, Italie, Égypte, États-Unis
- Colorado, District de Darmstadt, Hesse (Land), Lombardie, Île-de-France
- Créteil, Francfort-sur-le-Main, Milan
Links toward previous steps (curation, corpus...)
Le document en format XML
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Kondili</name><affiliation><nlm:affiliation>National Center for Global Health- Istituto Superiore di Sanità Rome Italy.</nlm:affiliation><wicri:noCountry code="no comma">National Center for Global Health- Istituto Superiore di Sanità Rome Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Aghemo, Alessio" sort="Aghemo, Alessio" uniqKey="Aghemo A" first="Alessio" last="Aghemo">Alessio Aghemo</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine and Hepatology Division, Humanitas Clinical and Research Center - IRCCS, Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal Medicine and Hepatology Division, Humanitas Clinical and Research Center - IRCCS, Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cai, Zongzhen" sort="Cai, Zongzhen" uniqKey="Cai Z" first="Zongzhen" last="Cai">Zongzhen Cai</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Dugan, Ellen" sort="Dugan, Ellen" uniqKey="Dugan E" first="Ellen" last="Dugan">Ellen Dugan</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Estes, Chris" sort="Estes, Chris" uniqKey="Estes C" first="Chris" last="Estes">Chris Estes</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gamkrelidze, Ivane" sort="Gamkrelidze, Ivane" uniqKey="Gamkrelidze I" first="Ivane" last="Gamkrelidze">Ivane Gamkrelidze</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ma, Siya" sort="Ma, Siya" uniqKey="Ma S" first="Siya" last="Ma">Siya Ma</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean Michel" last="Pawlotsky">Jean Michel Pawlotsky</name><affiliation wicri:level="3"><nlm:affiliation>National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, 94010 Créteil, France; INSERM U955, 94010 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, 94010 Créteil, France; INSERM U955, 94010 Créteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Razavi Shearer, Devin" sort="Razavi Shearer, Devin" uniqKey="Razavi Shearer D" first="Devin" last="Razavi-Shearer">Devin Razavi-Shearer</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Razavi, Homie" sort="Razavi, Homie" uniqKey="Razavi H" first="Homie" last="Razavi">Homie Razavi</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Waked, Imam" sort="Waked, Imam" uniqKey="Waked I" first="Imam" last="Waked">Imam Waked</name><affiliation wicri:level="1"><nlm:affiliation>National Liver Institute, Menoufia University, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>National Liver Institute, Menoufia University</wicri:regionArea><wicri:noRegion>Menoufia University</wicri:noRegion></affiliation></author><author><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine Department, Goethe University Hospital, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Internal Medicine Department, Goethe University Hospital, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Craxi, Antonio" sort="Craxi, Antonio" uniqKey="Craxi A" first="Antonio" last="Craxi">Antonio Craxi</name><affiliation wicri:level="1"><nlm:affiliation>Gastroenterology and Hepatology Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gastroenterology and Hepatology Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32777322</idno><idno type="pmid">32777322</idno><idno type="doi">10.1016/j.jhep.2020.07.042</idno><idno type="pmc">PMC7411379</idno><idno type="wicri:Area/Main/Corpus">000652</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000652</idno><idno type="wicri:Area/Main/Curation">000652</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000652</idno><idno type="wicri:Area/Main/Exploration">000652</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of COVID-19 on global hepatitis C elimination efforts.</title><author><name sortKey="Blach, Sarah" sort="Blach, Sarah" uniqKey="Blach S" first="Sarah" last="Blach">Sarah Blach</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States. Electronic address: sblach@cdafound.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Kondili, Loreta A" sort="Kondili, Loreta A" uniqKey="Kondili L" first="Loreta A" last="Kondili">Loreta A. Kondili</name><affiliation><nlm:affiliation>National Center for Global Health- Istituto Superiore di Sanità Rome Italy.</nlm:affiliation><wicri:noCountry code="no comma">National Center for Global Health- Istituto Superiore di Sanità Rome Italy.</wicri:noCountry></affiliation></author><author><name sortKey="Aghemo, Alessio" sort="Aghemo, Alessio" uniqKey="Aghemo A" first="Alessio" last="Aghemo">Alessio Aghemo</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine and Hepatology Division, Humanitas Clinical and Research Center - IRCCS, Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal Medicine and Hepatology Division, Humanitas Clinical and Research Center - IRCCS, Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cai, Zongzhen" sort="Cai, Zongzhen" uniqKey="Cai Z" first="Zongzhen" last="Cai">Zongzhen Cai</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Dugan, Ellen" sort="Dugan, Ellen" uniqKey="Dugan E" first="Ellen" last="Dugan">Ellen Dugan</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Estes, Chris" sort="Estes, Chris" uniqKey="Estes C" first="Chris" last="Estes">Chris Estes</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gamkrelidze, Ivane" sort="Gamkrelidze, Ivane" uniqKey="Gamkrelidze I" first="Ivane" last="Gamkrelidze">Ivane Gamkrelidze</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ma, Siya" sort="Ma, Siya" uniqKey="Ma S" first="Siya" last="Ma">Siya Ma</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean Michel" last="Pawlotsky">Jean Michel Pawlotsky</name><affiliation wicri:level="3"><nlm:affiliation>National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, 94010 Créteil, France; INSERM U955, 94010 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, 94010 Créteil, France; INSERM U955, 94010 Créteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Razavi Shearer, Devin" sort="Razavi Shearer, Devin" uniqKey="Razavi Shearer D" first="Devin" last="Razavi-Shearer">Devin Razavi-Shearer</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Razavi, Homie" sort="Razavi, Homie" uniqKey="Razavi H" first="Homie" last="Razavi">Homie Razavi</name><affiliation wicri:level="2"><nlm:affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Disease Analysis Foundation, Lafayette, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Waked, Imam" sort="Waked, Imam" uniqKey="Waked I" first="Imam" last="Waked">Imam Waked</name><affiliation wicri:level="1"><nlm:affiliation>National Liver Institute, Menoufia University, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>National Liver Institute, Menoufia University</wicri:regionArea><wicri:noRegion>Menoufia University</wicri:noRegion></affiliation></author><author><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine Department, Goethe University Hospital, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Internal Medicine Department, Goethe University Hospital, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Craxi, Antonio" sort="Craxi, Antonio" uniqKey="Craxi A" first="Antonio" last="Craxi">Antonio Craxi</name><affiliation wicri:level="1"><nlm:affiliation>Gastroenterology and Hepatology Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gastroenterology and Hepatology Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of hepatology</title><idno type="eISSN">1600-0641</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND & AIMS</b></p><p>COVID-19 has placed significant strain on national healthcare systems at a critical moment in the context of hepatitis elimination. Mathematical models can be used to evaluate the possible impact of programmatic delays on hepatitis disease burden. The objective of this analysis was to evaluate the incremental change in hepatitis C liver-related deaths and liver cancer, following a 3-month, 6-month, or 1-year hiatus in hepatitis elimination program progress.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Previously developed models were adapted for 110 countries to include a status quo or "no delay" scenario and a "1-year delay" scenario assuming significant disruption in interventions (screening, diagnosis and treatment) in the year 2020. Annual, country-level, model outcomes were extracted, and weighted averages were used to calculate regional (WHO and World Bank Income Group) and global estimates from 2020 to 2030. The incremental annual change in outcomes was calculated by subtracting the "no-delay" estimates from the "1-year delay" estimates.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The "1-year delay" scenario resulted in 44,800 (95% UI: 43,800 - 49,300) excess hepatocellular carcinoma (HCC) cases and 72,300 (95% UI: 70,600 - 79,400) excess liver-related deaths (LRDs), relative to the "no delay" scenario globally, from 2020-2030. Most missed treatments would be in lower-middle income countries, while most excess HCC and LRDs would be among high-income countries.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The impact of COVID-19 extends beyond the direct morbidity and mortality associated with exposure and infection. In order to mitigate the impact on viral hepatitis programming and reduce excess mortality from delayed treatment, policy makers should prioritize hepatitis programs as soon as it becomes safe to do so.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32777322</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0641</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>07</Day></PubDate></JournalIssue><Title>Journal of hepatology</Title><ISOAbbreviation>J. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>Impact of COVID-19 on global hepatitis C elimination efforts.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0168-8278(20)30523-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2020.07.042</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">COVID-19 has placed significant strain on national healthcare systems at a critical moment in the context of hepatitis elimination. Mathematical models can be used to evaluate the possible impact of programmatic delays on hepatitis disease burden. The objective of this analysis was to evaluate the incremental change in hepatitis C liver-related deaths and liver cancer, following a 3-month, 6-month, or 1-year hiatus in hepatitis elimination program progress.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Previously developed models were adapted for 110 countries to include a status quo or "no delay" scenario and a "1-year delay" scenario assuming significant disruption in interventions (screening, diagnosis and treatment) in the year 2020. Annual, country-level, model outcomes were extracted, and weighted averages were used to calculate regional (WHO and World Bank Income Group) and global estimates from 2020 to 2030. The incremental annual change in outcomes was calculated by subtracting the "no-delay" estimates from the "1-year delay" estimates.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The "1-year delay" scenario resulted in 44,800 (95% UI: 43,800 - 49,300) excess hepatocellular carcinoma (HCC) cases and 72,300 (95% UI: 70,600 - 79,400) excess liver-related deaths (LRDs), relative to the "no delay" scenario globally, from 2020-2030. Most missed treatments would be in lower-middle income countries, while most excess HCC and LRDs would be among high-income countries.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The impact of COVID-19 extends beyond the direct morbidity and mortality associated with exposure and infection. In order to mitigate the impact on viral hepatitis programming and reduce excess mortality from delayed treatment, policy makers should prioritize hepatitis programs as soon as it becomes safe to do so.</AbstractText><CopyrightInformation>Copyright © 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blach</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States. Electronic address: sblach@cdafound.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kondili</LastName><ForeName>Loreta A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>National Center for Global Health- Istituto Superiore di Sanità Rome Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aghemo</LastName><ForeName>Alessio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Internal Medicine and Hepatology Division, Humanitas Clinical and Research Center - IRCCS, Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Zongzhen</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dugan</LastName><ForeName>Ellen</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estes</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gamkrelidze</LastName><ForeName>Ivane</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Siya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawlotsky</LastName><ForeName>Jean Michel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, 94010 Créteil, France; INSERM U955, 94010 Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Razavi-Shearer</LastName><ForeName>Devin</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Razavi</LastName><ForeName>Homie</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Disease Analysis Foundation, Lafayette, Colorado, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waked</LastName><ForeName>Imam</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>National Liver Institute, Menoufia University, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeuzem</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Internal Medicine Department, Goethe University Hospital, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Craxi</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Gastroenterology and Hepatology Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Hepatol</MedlineTA><NlmUniqueID>8503886</NlmUniqueID><ISSNLinking>0168-8278</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">hepatitis C</Keyword><Keyword MajorTopicYN="N">mathematical modeling</Keyword><Keyword MajorTopicYN="N">viral hepatitis elimination</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32777322</ArticleId><ArticleId IdType="pii">S0168-8278(20)30523-7</ArticleId><ArticleId IdType="doi">10.1016/j.jhep.2020.07.042</ArticleId><ArticleId IdType="pmc">PMC7411379</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Infect Dis. 2014 Sep 15;59(6):765-73</Citation><ArticleIdList><ArticleId IdType="pubmed">24928290</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Gastroenterol Hepatol. 2017 Mar;2(3):161-176</Citation><ArticleIdList><ArticleId IdType="pubmed">28404132</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Surg. 2020 May;77:217</Citation><ArticleIdList><ArticleId IdType="pubmed">32305321</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Surg. 2020 Jun;219(6):900-902</Citation><ArticleIdList><ArticleId IdType="pubmed">32312477</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Égypte</li><li>États-Unis</li></country><region><li>Colorado</li><li>District de Darmstadt</li><li>Hesse (Land)</li><li>Lombardie</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Francfort-sur-le-Main</li><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Kondili, Loreta A" sort="Kondili, Loreta A" uniqKey="Kondili L" first="Loreta A" last="Kondili">Loreta A. Kondili</name></noCountry><country name="États-Unis"><region name="Colorado"><name sortKey="Blach, Sarah" sort="Blach, Sarah" uniqKey="Blach S" first="Sarah" last="Blach">Sarah Blach</name></region><name sortKey="Cai, Zongzhen" sort="Cai, Zongzhen" uniqKey="Cai Z" first="Zongzhen" last="Cai">Zongzhen Cai</name><name sortKey="Dugan, Ellen" sort="Dugan, Ellen" uniqKey="Dugan E" first="Ellen" last="Dugan">Ellen Dugan</name><name sortKey="Estes, Chris" sort="Estes, Chris" uniqKey="Estes C" first="Chris" last="Estes">Chris Estes</name><name sortKey="Gamkrelidze, Ivane" sort="Gamkrelidze, Ivane" uniqKey="Gamkrelidze I" first="Ivane" last="Gamkrelidze">Ivane Gamkrelidze</name><name sortKey="Ma, Siya" sort="Ma, Siya" uniqKey="Ma S" first="Siya" last="Ma">Siya Ma</name><name sortKey="Razavi Shearer, Devin" sort="Razavi Shearer, Devin" uniqKey="Razavi Shearer D" first="Devin" last="Razavi-Shearer">Devin Razavi-Shearer</name><name sortKey="Razavi, Homie" sort="Razavi, Homie" uniqKey="Razavi H" first="Homie" last="Razavi">Homie Razavi</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Aghemo, Alessio" sort="Aghemo, Alessio" uniqKey="Aghemo A" first="Alessio" last="Aghemo">Alessio Aghemo</name></region><name sortKey="Craxi, Antonio" sort="Craxi, Antonio" uniqKey="Craxi A" first="Antonio" last="Craxi">Antonio Craxi</name></country><country name="France"><region name="Île-de-France"><name sortKey="Pawlotsky, Jean Michel" sort="Pawlotsky, Jean Michel" uniqKey="Pawlotsky J" first="Jean Michel" last="Pawlotsky">Jean Michel Pawlotsky</name></region></country><country name="Égypte"><noRegion><name sortKey="Waked, Imam" sort="Waked, Imam" uniqKey="Waked I" first="Imam" last="Waked">Imam Waked</name></noRegion></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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